Public Health Trials Put Enterprise LLMs Under the Governance Microscope With FHIR-Linked Workflows

US public health agencies are preparing a hands-on proving ground for large language models from OpenAI and Anthropic, but the real story isn’t just that generative AI is coming to health departments—it’s that regulators and implementers are trying to operationalize trust, auditability, and clinical data handling before deployment scales.

The Coalition for Health AI (CHAI) and partners—including OpenAI, Anthropic, and Accenture—are launching the Public Health Use Case and Learning Scaling Engine (PULSE), a multi-jurisdiction programme designed to turn